Cathrine: Didn't Shakespear say lets kill all the lawyer.
Grissom: Yea Henry the 6th. Where is he when we need him.

[about a serial murderer]
Catherine Willows: When we zig, he zags.

You two ladies done talking?"

- [to Gil Grissom and Jim Brass] I-15 Murders

Catherine: Now, tell me, why are we here?
Grissom: Cause it's the only place within 10 miles of Calville Bay that serves calamari.
Catherine: And you know this because?
Grissom: I come here for... more

(Looking at the body of a woman who fell down the stairs)
Catherine: What are you thinking?
Grissom: Led Zepplin. Stairway To Heaven.

Death by smurf?

Grissom: You dont have a personal life?
Catherine: Write this down. I haven't had sex in 6-- No, seven monthes!
Grissom: How can i help?
(Catherines eyes widen)
Grissom: You. Advance, i mean.

Grissom! You can't possibly call that thing my office. It's a cupboard

Gil, only civilians confuse strippers and showgirls. You can't cheat the full monty.

I had to see with my own eyes. You're actually autopsying a bear.